Police were dispatched for a report of a motor vehicle accident involving injuries to the area of North 15th and Herr streets around 5 p.m., say police.
Upon arrival officers discovered that a motor vehicle traveling through the intersection had collided with pedestrians, causing critical injuries.
Two individuals were transported to hospital, one of which later died as a result of their injuries.
The Harrisburg Police Traffic Safety Unit responded to the scene and is conducting the investigation.
The investigation remains active.
Anyone with information is asked to contact the Harrisburg Police at 717-558-6900.
Click here to follow Daily Voice Lancaster and receive free news updates.